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Results Baseline characteristics In total, 111 patients with RA (mean age, 57 years

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Time from randomization to first cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke was analyzed using a Cox proportional hazards model with treatment as categorical fixed factor

These results demonstrate that TGF--induced transition from fibroblasts to myofibroblasts involves canonical TGF-/Smad2/3 signaling, non-canonical TGF-/ERK1/2 signaling, and ROS production via NAD(P)H oxidase

While these findings underscore the promise of incretin therapies for OSA management, the review emphasizes the need for long-term follow-up to assess durability of benefit and monitor safety